Self-immolative dendritic

ELIMINATION-BASED AB3 SELF-IMMOLATIVE DENDRITIC AMPLIFIER... 

FIGURE 5.8 Disassembly mechanism of AB3 self-immolative dendritic molecule 13. 

FIGURE 5.10 Chemical structures of AB3 self-immolative dendritic molecules with tryptophan tail units and a trigger that is activated by PGA. 

FIGURE 5.16 AB3 self-immolative dendritic system with diphenylalanine end units and a trigger designed for activation by PGA. 

FIGURE 5.21 Molecular structure of a single-triggered AB6 self-immolative dendritic... 

Sagi, A. Segal, E. Satchi-Fainaro, R. Shabat, D. Remarkable drug-release enhancement with an elimination-based AB3 self-immolative dendritic amplifier. Bioorg. Med. Chem. 2007, 15, 3720-3727. 

Shamis, M. Lode, H. N. Shabat, D. Bioactivation of self-immolative dendritic prodrugs by catalytic antibody 38C2. J. Am. Chem. Soc. 2004, 126, 1726-1731. 

Amir, R. J. Danieli, E. Shabat, D. Receiver-amplifier, self-immolative dendritic device. Chem. Eur. j. 2007, 13, 812-821. 

AB3 single-triggered self-immolative dendritic adaptors. 

FIGURE 5.38 Disassembly pathway of AB2 self-immolative dendritic molecule 39. 

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