Seleno-DL-methionine

Breeding adults fed diets for 100 days containing 0, 1,2, 4, 8, or 16 mg Se/kg fresh weight (FW) ration as seleno-DL-methionine, or 16 mg Se/kg ration as seleno-DL-cysteine Breeding adults fed diets containing 0,... 

Day-old mallard ducklings fed diets for 2 weeks containing 0, 15, or 30 mg Se/kg ration in a 75% wheat diet (22% protein). Selenium given as seleno-DL-methionine, seleno-L-methionine, or selenized yeast... 

Adult males fed diets containing 0,10, 20, 40, or 80 mg Se/kg ration as seleno-DL-methionine for 16 weeks... 

Mallards fed diet containing 0 or 15 mg Se/kg ration as seleno-DL-methionine for 21 weeks, untreated food for 12 weeks, followed by 100 mg Se/kg ration for 5 weeks for both groups Adults fed diet containing 10 mg Se/kg ration as selenomethionine for 6 weeks followed by 6 weeks on untreated diet... 

Heinz, G.H., D.J. Hoffman, and L.J. LeCaptain. 1996. Toxicity of seleno-L-methionine, seleno-DL-methionine, high selenium wheat, and selenized yeast to mallard ducklings. Arch. Environ. Contamin. Toxicol. 30 93-99. 

Seleno-DL-methionine ( 2-amino-4-methylselanylbutyric acid) [2578-28-1 ] M 196.1, m 265 (dec), 267-269 (dec), 270 . Crystallises in hexagonal plates from MeOH and H2O. [Klosterman and Painter JACS 69 2009 1949]. The L-Isomer is purified by dissolving in H2O, adjusting the pH to 5.5 with aqueous NH3, evaporating to near-dryness, and the residue is washed several times with absolute EtOH till solid is formed and then recrystd from Me2CO. It has m 266-268°(dec), 275°(dec), [a] -(-18.1°(c 1, N HCI). [Pande et al. JOC 35 1440 1970]. 

Maier, K.J. and Knight, A.W. (1993) Comparative acute toxicity and bioconcentration of selenium by the midge Chironomus decorus exposed to selenate, selenite, and seleno-DL-methionine, Archives of Environmental Contamination and Toxicology 25 (3), 365-370. 

M. R. Da Silva, R. M. Olivas, O. F. X. Donard, M. Lamotte, Determination of the deprotonation constants of seleno-DL-cystine and seleno-DL-methionine and implication to their separation by HPLC, Appl. Organomet. Chem., 11 (1997), 21-30. 

Panter KE, Hartley WJ, James LF. 1996. Comparative toxicity of selenium from seleno-DL-methionine, sodium selenate, and Astragalus bisulcatus in pigs. Fund Appl Toxicol 32 217-223. 

Selenium and arsenic are antagonists in several animal species. Dietary arsenic, as arsenate, alleviates the toxic effects of selenium, as seleno-DL-methionine, on mallard (Anas platyrhynchos) reproduction, duckling growth, and survival. Mallard ducklings fed arsenate in the diet at 200.0 mg As/kg ration were protected against the toxic effects... 

---