Selectors imprinted chiral phases

Chromatography. Chromatography (HPLC, GC, and TLC) is commonly used in characterization of chiral drugs and has consequently been used in the evaluation of chiral excipient-drug interactions. Many authors have used HPLC to study stereoselectivity between chiral excipients and drugs [3,8,9,40-42]. The columns used in these studies range form octa-desylsilane to chiral selectors such as Chiral AG and molecularly imprinted stationary phases. 

Chiral separations by CE and CEC are achieved using a chiral selector which is either free in the mobile phase or immobilised to the stationary phase. MIPs can be used as the selector in both approaches. Molecularly imprinted capillary columns... 

Optical isomer separations that are carried out on a chiral layer produced from C-18 modified silica gel impregnated with a Cu(II) salt and an optically active enantiomerically pure hydroxyproline derivative, on a silica layer impregnated with a chiral selector such as brucine,on molecularly imprinted polymers of alpha-agonists,or on cellulose with mobile phases having added chiral selectors such as cyclodextrins have been reported mostly for amino acids and their derivatives. Mixtures of sorbents have been used to prepare layers with special selectivity properties. 

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