Selection Pathfinder

PATHFINDER ELEMENT, An element present in small proportions less than 1 % generally metallic in nature, associated with ore deposits at the time of formation. Mapping of the concentration variation of the selected element serves to locate the main ore deposit Examples are zinc as the pathfinder for lead, copper, and silver ores, and molybdenum associated with copper deposits. 

Osbourn JK, Derbyshire EJ, Vaughan TJ, Field AW, Johnson KS, Pathfinder selection in situ isolation of novel antibodies, Immunotech., 3 293-302, 1998. 

The Pathfinder approach was used to compare the CYP cavities of CYP2C9 [8], 2D6 [9], and 3A4 [10], the most important human cytochrome enzymes. CYP2C9 and 3A4 were available as protein crystal structures whilst an homology model was used for 2D6. Frequency distribution plots (Fig. 5.8) were obtained from non-superposed CYP structures, selecting the iron in the heme moiety as a root departure path. 

The second section refers to pharmacodynamic aspects and contains chapters on Protein selectivity studies using GRID-MIE by Thomas Fox, The Complexity of Molecular Interaction Molecular Shape Fingerprint by PathFinder Approach by McLay, Hann, Carosati, Cruciani, and Baroni, Alignment-Independent Descip-tors from Molecular Interaction Fields by Manuel Pastor, FLAP 4-point pharma-... 

---