Selectin ligands soluble

Wang K, Zhou Z, Zhou X, et al. Prevention of intimal hyperplasia with recombinant soluble P-selectin glycoprotein ligand-immunoglobulin in the porcine coronary artery balloon injury model, J Am Coll Cardiol 2001 38 577-582,... 

WuT, Xie C, Wang FIW, Zhou XJ, Schwartz N, Calixto S, Mackay M, AranowC, Putterman C, Mohan C. Elevated urinary VCAM-1, P-selectin, soluble TNF receptor-1, and CXC chemokine ligand 16 in multiple murine lupus strains and human lupus nephritis. J Immunol. 2007 179 7166-7175. 

Adhesion molecules are a wide variety of molecules that can potentially be measured as a way of assessing the adherence of leukocytes and/or platelets or other adhesive proteins to the endothelial matrix. Some are receptors. Some of the examples include PECAM-1 (platelet-endothelial adhesion molecule 1), P-selectin, e-selectin, and VCAM-1 (vascular cell adhesion molecule i). At times, the receptor itself is measured but often it is a soluble portion that circulates that is the ligand. At present, there are no standardized assays and no reference interval studies or consistent assay validations. 

Figure 4 shows the allometric plots of pharmacokinetic parameters for the recombinant, soluble, and chimeric form of P-selectin glycoprotein ligand-1 (rPSGL-Ig), an antagonist to P-selectin for the treatment of P-selectin-mediated diseases like thrombosis, reperfusion injury, and deep vein thrombosis. Human rPSGL-Ig pharmacokinetic parameters could accurately be predicted on the basis of data from mouse, rat, monkey, and pig using allometric power functions [54]. 

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