Selected Biological Aspects

3 Selected Biological Aspects. - The catalytic antibody-mediated hydrolysis of the insecticide paraoxon (100) and analogues 101 have been investigated with a view to developing antibodies for use in the treatment of insecticide poisoning. Two-dimensional inverse NMR spectroscopy has been applied to the 

Enzyme-catalysed desulfuration of steroids plays an important role in steroid biosynthesis and may provide a source of steroids in the growth and proliferation of breast cancer. Inhibition studies of estrone sulfatase with both steroidal and non-steroidal phosphate compounds have now shown that the best inhibitors contain phosphate mono anions and that the basic structure for inhibition does not require the steroid nucleus.  

The glycoside phosphoramidate (145) has potential as a pro-drug for use in conjunction with gene-directed therapy since (145) is readily transformed into the phosphorus mustard agent (146) when incubated with E. coli p-galac-tosidase.  

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Selected Biological Aspects. - It has been shown that in the co-transla-tional transfer of a tetradecasaccharide (Glc3Man9GlcNAc2-)(147), which is the asparagine residue of a nascent polypeptide chain inside the lumen of endoplasmic reticulum, N-glucosylation is catalysed by the enzyme oligosaccharyl trans-... 

Selected Biological Aspects. - The design and preparation of haptens (390) and (391) for catalytic antibody-promoted dynamic kinetic resolution of racemic 4-substituted 4H-oxazolin-5-ones have been reported. Transition state mimicry and a bait and switch strategies were adopted to propose the structure of the haptens. A key step in their synthesis is based on a ring-closing metathesis reaction. ... 

Selected Biological Aspects. - Phosphonate and phosphinic acids and their derivatives have been widely used in haptens. Examples additional to those already discussed in other sections include the phosphonic acid anion 363 which was an alternative to the preferred but synthetically inaccessible structure 364. The mechanism-based probe 365 has been synthesised and shown to modify a bacterial phosphotriesterase. This strategy for generating a probe is general and should allow the isolation of a host of unique catalysts. ... 

It should be noted that these biomimetic approaches do not completely mimic nature rather, just selected biological aspects are mimicked. However, if selected biomimetic aspects are rationally... 

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