Seizure liability testing

2 Medium/High Throughput Approaches to Assess Seizure Liability of Drug Candidates 

1 In Vivo Zebra Fish Larvae The zebra fish larvae (Danio rerio Zf) have been assessed as a medium/ high-throughput in vivo model for detection of seizure liability (Baraban et al., 2005 Winter et al., 2008). Exposure 

There are two main types of in vivo seizure models, precipitant models and electroencephalogram (EEG) recording. These are generally used where there is known target-related risk or to follow-up on behavioral observations seen in other in vivo studies. 

PREDICTING ORGAN TOXICITY IN V/VO—CENTRAL NERVOUS SYSTEM 

---

As a result of improved selectivity, ABT-594 is safer than epibatidine in in vivo testing. The separation between antinociceptive doses and lethal doses in mice is fivefold greater for ABT-594 than it is for epibatidine.37 Similarly, ABT-594 has less seizure liability than epibatidine in mice and displays less cardiovascular toxicity in dogs.37,38... 

---