Secretion, glycoprotein role

The mechanisms of HIV-associated DSP are incompletely understood. Over the years, various hypotheses have been put forward, but recent data suggest that multiple mechanisms are likely to play a role in neuronal or axonal injury in DSP. These processes may be mediated by direct neurotoxicity of HIV or secreted viral proteins such as the envelope glycoprotein gpl20, or by indirect mechanisms... 

Finding a Role for PC on Secreted Filarial Nematode Glycoproteins... 

Hunter, J., Hirst, B. H., Intestinal secretion of drugs the role of P-glycoprotein and related drug efflux systems in limiting oral drug absorption, A dr. Drug Del. Rev. 1997, 25, 129-157. 

C. D., Characterization of MMP+ secretion across human intestinal Caco-2 cell monolayers role of P-glycoprotein and a novel Na+-dependent organic cation transport... 

The mucous secretions are vital, as they act as lubricants and defensive agents, in cavities of the body communicating with the environment, or on body surfaces.229 415 418 452 The influence of sialic acids on the macromolecular conformation seems to be the reason for the proteolytic resistance of several sialo-glycoproteins. The first example of such a role for sialic acids came from studies by Faillard and Pribilla453 that demonstrated a loss of the... 

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