Secondary amides synthesis from acid chlorides

A simple example of using combinatorial chemistry to prepare a library of small molecules is the synthesis of secondary amides (9.46) from primary amines (9.44) and acid chlorides (9.45) (Scheme 9.4). Amides of type 9.46 have two points of variation the R-group of the amine and the R -group from the acid chloride. A third point of variation may be introduced by V- a I k y I ation with an alkyl halide (9.47) to form a tertiary amide (9.48). With just 15 building blocks—five amines, five acid chlorides, and five alkyl halides—125 (53) different tertiary amides may be prepared. 

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