Second generation P-blocker

Second generation P-blockers have greater cardio-selectivity and are less likely to cause bronchoconstriction. Examples are atenolol and bisoprolol. 

It has been stated earlier that the first generation and the second generation P-blockers essentially possess either isopropyl or tertiary-huiyX functional moieties attached to the N-alkyl groups. 

The term antihistamine, without a modifying adjective, refers to the classic Hi receptor blockers. These compounds do not influence the formation or release of histamine, but rather they competitively block the receptor-mediated response of a target tissue. [Note This contrasts with the action of cromolyn (see p. 220), which inhibits the release of histamine from mast cells and is useful in the treatment of asthma.] The H receptor blockers can be divided into first- and second generation drugs.(Figure 40.5). The first generation drugs are still widely used because they are effective and inexpensive. 

Lapointe N, Chen H, Qi S, Xu D, Daloze P, Dumont L. Immunomodulating effects of second-generation calcium channel blockers on experimental heart transplantation. Eur Surg Res 1999 31 259-266. 

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