Prajmaline Bitartrate

Therapeutic Function Antiarrhythmic Chemical Name 17R,21Ct-Dihydroxy-4-propylajmalaniun Common Name -Structural Formula  

1 g of aimallne was dissolved in 4 cc of chloroform, and 1 cc of allyl bromide was added to the resulting solution. The reaction mixture thus obtained was allowed to stand for 24 hours at room temperature. Thereafter, the clear reaction solution was briefly cooled to a temperature below 0°C, whereby crystallization set in. The crystals were filtered off and were then recrystallized from a mixture of absolute methanol and absolute ether. The purified colorless crystalline product was identified to be N-(b)-allyl-aimalinium-bromide having a melting point of 252°C to 254°C. 

75 g of N-(b)-n-propy I-aj mailnium-bromide were suspended in 3 liters of an aqueous saturated solution of sodium bicarbonate, and the suspension was admixed with 3 liters of chloroform. The resulting mixture was vigorously stirred for six to eight hours. Thereafter, the chloroform phase was separated and evaporated to dryness. 68 g of a yellow syrup remained as a 

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Prajmaline bitartrate Secobarbital sodium T rioxsalen Allyl carbamide Meralluride... 

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