Searching for Drugable Targets to Cure or Slow Down Alzheimer Disease

Searchingfor DrugableTargets TO Cure or Slow Down Alzheimer Disease 

The clues—often misleading—come from rigorous observation. The Alzheimer brain is invaded by so-called plaques and tangles that disrupt interneural communication. The amyloid plaques kill neurons and create a cholinergic deficit—and large deficits in other neurotransmitters as well— which manifests as a loss of memory and recognition of, for example, family members, and can cause behavioral problems, even violence. But the pathological and biochemical manifestations of 

Development SIN Store for Other Psychiatric AND Neurological Disorders 

IBB pqj. example, a Swedish double mutant of APP (Amyloid A4-Protein Precursor) correlates with early onset and overproduction of amyloid peptide A 1-40/42, and an ApoE4 isoform correlates with propensity for AD. 

Box 29.2 CNS Drugs for Alzheimer Disease, Major Depr essive Disorder, Parkinson Disease, and Multiple Scler osis 

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