Search NIOSH RTECS

G. NIOSH RTECS Search System. The National Institute for Occupational Safety and Health (NIOSH), created in 1970, is required by law to prepare a list containing all the toxic effects of chemicals that can be found to have been recorded (24). The Registry of Toxic Effects of Chemical Substances (RTECS) is the data base created and updated annually by NIOSH to fulfill the provisions of this law. In 1977 the data base consisted of some 25,000 chemicals and the toxicity associated with these chemicals. 

The RTECS data base can be searched in a number of ways, including NIOSH number, CAS Registry number, type of animal tested, route of dosage, LD50. LC50, etc. The NIOSH RTECS file is also linked to the SSS so that structure-activity correlation work can be performed. 

An example of a NIOSH RTECS search is shown in Figure 7. In this example, a search is being performed for all oral rodent LD50 toxicity data with values less than 75 ug./kg. of which the system indicates there are 3. The bottom of Figure 7 shows these three references, with the NIOSH number, toxicity data and the literature citation for that measurement. 

NIOSH, Registry of Toxic Effects of Chemical Substances (RTECS) (http //www.cdc.gov/niosh/ rtecs.html, http //ccinfoweb.ccohs.ca/rtecs/search.html). 

An example of a CIDS key search is given in Figure 7, where a search is shown for all cyclohexyl (SCN49) morpholine (SCN35) compounds in the NIOSH RTECS data base of acute toxicity. There are only two such compounds in the data base, and the first of these is printed out in the figure, along with its local NIOSH RTECS identifier numbers indicated. 

The command to do this is EXIM, which is short for EXact/IMbed switch. The search shown in Figure 11 reveals that there are 2715 compounds in the NIOSH RTECS file that contain at least this ring pattern. To filter such potentially broad responses further, one can use CIDS keys searches and other such constraints as shown below. 

After the fragment search is conducted for the chloro aromatic fragment, a similar search is performed on the fragment centered about atom 2, which contains a bromo substituent. This fragment probe (FPROBE) search, shown in Figure 13, results in 229 occurrences of this fragment in compounds in the NIOSH RTECS data base. 

The Registry of Toxic Effects of Chemical Substances. The Registry of Toxic Effects of Chemical Substances (RTECS) [70] is a database of toxicological information compiled, maintained, and updated by the National Institute for Occupational Safety and Health (NIOSH). The Occupational Safety and Health Act of 1970 mandated the program. RTECS now contains over 133,000 chemicals as NIOSH strives to fulfill the mandate to list all known toxic substances and the concentrations at which toxicity is known to occur. This database is available for searching through the GOV. Research Center (GRQ service at http // grc.ntis.gov by subscription or by a day pass. 

CAS = Chemical Abstracts Services DOT/UN/NA/IMCO = Department of Transportation/United Nations/North America/International Maritime Dangerous Goods Code EPA = Environmental Protection Agency HSDB = Hazardous Substances Data Bank NCI = National Cancer Institute NIOSH = National Institute for Occupational Safety and Health OHM/TADS = Oi1 and Hazardous Materials/Technical Assistance Data System RTECS = Registry of Toxic Effects of Chemicals Substances SANSS = Structure and Nomenclature Search System... 

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