Search for Functional Group Exchanges GRX

One of the classic paradigms of crystal engineering is the notion of chloro/methyl interchange, where it is observed that pairs of molecules differing only by interchange of a chloro substituent for a methyl group can adopt identical crystal structures [34]. One question that we might reasonably expect to answer by consultation of the CSD is how often is isostructurality observed for pairs of chloro/methyl substituted molecules The conceptual steps required to answer such a question are as follows  

Clearly, this is a task that is beyond manual manipulation of the ConQuest software, becoming intractable at step (4). To automate this type of process, the GRX program has been developed [35], 

---