Screening trials

Shoptaw S., Watson D.W., Reiber C. et al. Randomized controlled pilot trial of cabergoline, hydergine and levodopa/carbidopa Los Angeles Cocaine Rapid Efficacy Screening Trial (CREST). Addiction. 100(Suppl. 1) 78, 2005. 

Winhusen T.M., Somoza E.C., Harrer J.M. et al. A placebo-controlled screening trial of tiagabine, sertraline and donepezil as cocaine dependence treatments. Addiction. 100(Suppl. 1) 68, 2005. 

Intrathecal therapy may be considered an alternative to destructive neurosurgical procedures. Prior to implantation of a device for chronic intrathecal infusion, patients must show a response in a screening trial. 

Infection Patients should be infection-free prior to the screening trial with baclofen injection because the presence of a systemic infection may interfere with an assessment of the patient s response. 

Fourth, and finally, Rausser and Small seem to have assumed, like so many scientists until recendy, that organisms have evolved only to retain biologically active NPs, as if organisms were doing the hrst stage of a screening trial on behalf of humans. As explained in Chapter 5, the Screening Hypothesis, based on well-established physicochemical principles, postulates that most NPs are simply members of the NP library that the natural world has made. Like individual chemicals in the libraries of synthetic chemicals made by humans, most of the chemicals will possess no potent biomolecular activity. 

Table 18.1 Known and possible female-produced sex pheromone components for arctiid moths. Compounds in bold have been found in pheromone gland extracts or aeration extracts and have been shown to be active in behavioral bioassays or field trials compounds in normal font have been found in pheromone gland or aeration extracts and compounds in italics have been shown to attract males infield screening trials.

Trial procedures (screening, trial period, follow-up, assessments)... 

Clinical trials are formal research studies investigating the efficacy of a particular drug or other type of modality on a selected disease or condition. There are different types of trials. For example, there are treatment, prevention, and screening trials in the case of cancer. Clinical trials are classified into three phases. A phase-I trial investigates a product s safety on a small study population. Phase-II tests the efficacy over a longer period of time. Phase-III studies are usually randomized and controlled, involving a large study population, and may last several years. These trials compare the protocol under study to the current standard. 

Gohagan JK, Prorok PC, Kramer BS, et al. The prostate, lung, colorectal, and ovarian cancer screening trial of the National Cancer Institute. Cancer 1995 75 1869-1873. 

For women without a family history of ovarian cancer or with a family history of ovarian cancer in one relative, routine screening with ultrasound or CA-125 is not recommended because current evidence does not snpport any benefit. Participation in ovarian cancer screening trials is appropriate. 

Vogt, M. and Bajorath, J. (2007b) Introduction of an information-theoretic method to predict recovery rates of active compormds for Bayesian in silica screening theory and screening trials./, Chem. Inf. Model, 47, 337-341. 

The effect of pH on protein solubility is significant and is one of the common variables in early screening trials. Generally, the solubility will change dramatically as pH is altered by roughly... 

H.G. Juffs, I.F. Tannock (2002). Screening trials are even more difficult than we thought they were. Editorial. J. Natl. Cancer Inst., 94, 156-157. 

R.J. Van Klaveren, H.J. de Koning, J. Mulshine, et al. (2002). Lung cancer screening by spiral CT. What is the optimal target population for screening trials. Lung Cancer, 38, 243-252. 

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