Prion proteins scrapie

Gasset, M., Baldwin, M. A., Fletterick, R.J., and Prusiner, S. B. (1993). Perturbation of the secondary structure of the scrapie prion protein under conditions that alter infec-... 

Pan, K. M., Baldwin, M., Nguyen, J., Gasset, M., Serban, A., Groth, D., Mehlhorn, I., Huang, Z., Fletterick, R. J., Cohen, F. E., and Prusiner, S. B. (1993). Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins. Proc. Natl. Acad. Sci. USA 90, 10962-10966. 

Taraboulos, A., Serban, D., and Pmsiner, S. B. 1990. Scrapie prion proteins accumulate in the cytoplasm of persistently infected cultured cells. J. Cell Biol. 7/0 2117-2132. 

Pmsiner SB, Groth DF, Bolton DC et al (1984) Purification and structural studies of a major scrapie prion protein. Cell 38 127-134... 

Pan KM, Baldwin M, Nguyen J et al (1993) Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins. Proc Natl Acad Sci USA 90 10962-10966... 

Wille H, Michelitsch MD, Guenebaut V et al (2002) Structural studies of the scrapie prion protein by electron crystallography. Proc Natl Acad Sci USA 99 3563-3568... 

Atarashi R, Moore RA, Sim VL et al (2007) Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion protein. Nat Methods 4 645-650... 

Smirnovas V, Kim J, Lu X et al (2009) Distinct structures of scrapie prion protein (PrPSc)-seeded versus spontaneous recombinant prion protein fibrils revealed by hydrogen/deuterium exchange. J Biol Chem 284 24233-24241... 

Peretz D, Scott MR, Groth D et al (2001) Strain-specified relative conformational stability of the scrapie prion protein. Protein Sci 10 854—863... 

Cali I, Castellani R, Alshekhlee A et al (2009) Co-existence of scrapie prion protein types 1 and 2 in sporadic Creutzfeldt-Jakob disease its effect on the phenotype and prion-type characteristics. Brain 132 2643-2658... 

Stahl N, Borchelt DR, Hsiao K, Prusiner SB (1987) Scrapie prion protein contains a phosphatidylinositol glycolipid. Cell 51 229... 

Borchelt DR, Taraboulos A, Prusiner SB (1992) Evidence for synthesis of scrapie prion proteins in the endocytic pathway. J Biol Chem 267 16188... 

Endo T, Groth D, Prusiner SB, Kobata A (1989) Diversity of oligosaccharide structures linked to asparagines of the scrapie prion protein. Biochemistry 28 8380... 

Tatzelt J, Prusiner SB, Welch WJ (1996) Chemical chaperones interfere with the formation of scrapie prion protein. EMBO J 15 6363... 

Oesch, B., Teplow, D.B., Stahl, N., Serban, D., Hood, L.E., and Prusiner, S.B. (1990). Identification of cellular proteins binding to the scrapie prion protein. Biochemistry 29, 5848-5855. 

Hay, B., Barry, R.A., Lieberburg, S.B., Rrusiner, S.B., and Lingappa, V.R. (1987a). Biogenesis and transmembrane orientation of the cellular isoform of the scrapie prion protein. Mol. Cell Biol. 7, 914-920. 

Bessen, RA., Kodsko, DA., Raymond, G.J., Nandan, S., Landsbury, RT., and Caughey, B. (1995). Non-genetic propagation of strain-spedfic properties of scrapie prion protein. Nature S75, 698-700. 

Naslavsky N, Shmeeda H, Ftiedlander G, Yanai A, Futerman AH, Barenholz Y, Taraboulos A (1999) SphingoUpid depletion increases formation of the scrapie prion protein in neuroblastoma cells infected with prions. J Biol Chem 274 20763-20771... 

Soto, C. 2006. Prions. The New Biology of Proteins. CRC Press, Boca Raton, USA Stahl, N., Borchelt, D. R., and Prusiner, S. B. 1990. Differential release of cellular and scrapie prion protein form cellular membranes of phosphatidylinositol specific phospholipase. Biochemistry 29 5405-5412... 

Westaway, D. and Prusiner, S. B. 1986. Conservation of the ceUnlar gene encoding scrapie prion protein. Nncleic Adds Res. 14 2035—2044... 

Insight from Electron Crystallography for a Working P-structure of Scrapie Prion Protein... 

Figure 7.37. Possible structural model of scrapie prion protein from electron crystallography studies, showing full sixfold symmetric top view with triangular arrangement of parallel P-pleated sheets at the center surrounded by additional partially a-helical sequences. (Reproduced with permission from Wille et al. Copyright 2002 National Academy of Sciences, U.S.A.)...

Subsequently, the physiological, unaltered form of the prion was called PrP " for the cellular prion protein and the pathologic, altered form was called PrP , derived from the scrapie prion protein. 

---