Schreiber, Stuart

Schreiber, Stuart L. (2000). Target-Oriented and Diversity-Oriented Organic Synthesis in Drag Discovery. Science 287 1964—1969. 

Schreiber, Stuart L., Kapoor, Tarun M., Wess, Gunther (eds.)... 

The first (+)-discodermolide synthesis was completed by Stuart Schreiber s group at Harvard University and is outlined in Scheme 13.68. This synthesis was carried through for both enantiomers and established the absolute configuration of the natural material. The retrosynthetic plan outlined in Scheme 13.67 emphasizes the stereochemical triads found at C(2)-C(4), C(10)-C(12) and C(18)-C(20) and was designed to use a common chiral starting material. Each of the segments contains one of the stereochemical triads. 

Prof. Stuart L. Schreiber Chemical Labotatories Harvard University 12, Oxford Street... 

I am grateful to Stuart L. Schreiber for generously sharing unpublished information from his laboratory. L. Wayne Schultz helped prepare the illustrations. I am grateful to the National Institutes of Health (Grant R01-CA59021) for financial support. 

Submitted by Ronald E. Claus and Stuart L. Schreiber. Checked by Nakcheol Jeong and Martin F. Semmelhack. 

The need for this series was evident from the enthusiastic response from the scientific community in the most meaningful way — their willingness to devote their time to the task. 1 am deeply indebted to an exceptional board of editors, beginning with my deputy editor-in-chief Ian Fleming, and extending to the entire board — Clayton H. Heathcock, Ryoji Noyori, Steven V. Ley, Leo A. Paquette, Gerald Pattenden, Martin F. Semmelhack, Stuart L. Schreiber and Ekkehard Winterfeldt. 

STUART L. SCHREIBER, Harvard University,Cambridge, Massachusetts, USA... 

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