Schollkopf synthesis

For convenience, this alkylation section is subdivided into two subsections, the first covering various regular C-alkylation processes and the second outlining some typical C-alkylations as used in the Schollkopf synthesis. 

One of the classics is the Schollkopf synthesis via bislactim ethers [7]. Beside efficient methods for the preparation of bislactim ethers [8], a derivative of 1 with R = C02Et has been used for the synthesis of a-alkylated serines [9], and a derivative of 1 with R = H has been used in a... 

In the Schollkopf synthesis, a-metalated isocyanides 13 (from isocyanides and /z-butyllithium) react with acid chlorides to give 4,5-disubstituted oxazoles 14 via C-acylation and electrophilic C-O bond formation. 

Lau, H.H., and U. Schollkopf Synthesis of N-Hydroxy-a-amino Acids by Alkylation of N-Benzylidene-a-amino Acid Methyl Ester N-Oxides. Liebigs Ann. Chem. 1981, 1378. 

Based on the Schollkopf synthesis, a fiiUy automatized continuous-flow synthesis has been developed [264], in which EWG-substituted methyl isocyanides are reacted with... 

Sandmeyer synthesis (isatin) 145 Schmidt-Druey synthesis (pyridazine) 461 Schollkopf synthesis (oxazole) 173 Sharpless-Katsuki epoxidation 24 Shaw synthesis (pyrimidine) 468 Skraup-Doebner-Miller synthesis (quinoline) 400 Smiles rearrangement 446 Sommelet-Hauser rearrangement 136 Staudinger reaction 53 Steglich reagent (DMAP) 348 Stork isoxazole annelation 191... 

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