Schlotterbeck

Ring enlargement of benzene derivatives by carbenes generated from diazo compounds (better in the presence of a Rh catalyst) Conversion of aldehydes to ketones by diazo compounds (Schlotterbeck) see also Ptau Planer... 

Schlotterbeck and Watkins also recorded diphylline, m.p. 216°, which Manske suggests is dZ-stylopine (tetrahydrocoptisine), and sanguinarine, which Manske could not confirm. ... 

Adlumine and Adlumidine. (Items 1, 21, 24, 25, 29 list, p. 169). From Adlumia cirrhosa Rap. Schlotterbeck isolated two alkaloids, adlumine, C3,H3 09N(0H)(0Me)2, m.p. 188, [ ]d + 39-88°, and adlumidine, C30H29O9N, m.p. 234°. Manske used these two names for alkaloids isolated from A. fungosa Greene, stated to be identical with A. cirrhosa Rap., and suggested (I) that Schlotterbeck s adlumine was probably bicuculline with some adlumine and (II) that the two adlumidines are identical. 

Manske has shown that the stylopine of Schlotterbeck and Watkins, C19H49O5N, m.p. 202°, [a]r, — 315-2° (item 61 list, p. 173), is Z-tetra-hydrocoptisine he has recorded its presence in three other plants (items 12, 15, 44 list, pp. 170-3) and suggested that dipZij/ZZZne (item 61) is dZ-stylopine, i.e., dZ-tetrahydrocoptisine. He has also proposed that the name stylopine being simpler than, and having priority over tetrahydrocoptisine, should replace the latter. Each of these names is used in the lists (pp. 169-173), as recorded by the author concerned, in order to avoid confusion. 

Ross A, Schlotterbeck G, Klaus W et al (2000) Automation of NMR measurements and data evaluation for systematically screening interactions of small molecules with target proteins. JBiomol NMR 16 139-146... 

Figure 7.34 Contour plot of chemical shift vs. retention time, and reconstructed chromatogram of an FAE-based surfactant (Table 7.71). After Schlotterbeck et al. [655]. Reproduced from G. Schlotterbeck et al., Polym. Bull, 38, 673-679 (1997), by permission of Springer-Verlag, Copyright (1997)...

G.E. Martin, R.C. Crouch and A.P. Zens, Magn. Reson. Chem., 36 (1998) 551-557 for 1.7 mm sensitivity G. Schlotterbeck, A. Ross, R. Hoch-strasser, H. Senn, T. Kuhn, D. Marek and O. Schett, Anal. Chem., 74 (2002) 4464 for 1mm Bruker probe performance M.E. Lacey, R. Subra-manian, D.L. Olsen, A.G. Webb and J.V. Sweedler, Chem. Rev., 99 (1999) 3133-3152 General review of small volume probe performance. 

We thank BIP Chemicals Ltd., for Research Studentships to PHW and FRJ, the British Council and the Turkish Cultural Ministry for support of YF, the British Science Research Council for funds for equipment and technical help, the National Research Development Corporation for support of the work on crown ethers, and Dr. D. Schlotterbeck for instructing us in the Jaacks ethoxide method. 

We would especially like to thank Dr. D. Nietlispacli and Dr. G. Wider for very useful comments on the manuscript. The authors are indebted to Gotz Schlotterbeck (F. Hoff-mann-La Roche AG, Basel, Switzerland) and Till Kuhn (Bruker BioSpin AG, Fallanden, Switzerland) for providing the data for Fig. 3.6. 

We gratefully acknowledge the contributions of and discussions with our colleagues at Hoffmann-LaRoche, Basel B. Gsell, A. Ross and G. Schlotterbeck. We also thank F. Dela-glio for making available his software. 

The reaction, as originally carried out, is of little contemporary use. Metal-mediated catalysis is more-often applied, where the reactive species are metal carbenoids. Buchner-Curtius-Schlotterbeck Reaction... 

A Holtzel, G Schlotterbeck, K Albert, E Bayer. Separation and characterisation of hop bitter acids by HPLC- H-NMR coupling. Chromatographia 42 499-505, 1996. 

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