Scandium complexes amino acids

The other direction concerns the use of immobilized transition metal catalysts in the synthesis of libraries of organic compounds of interest in therapeutic drug discovery. One such strategy uses immobilized catalysts (e.g., scandium complexes), leading to efficient library syntheses of quinolines, amino ketones, and amino acid esters.72,73... 

Scandium complexes, 1059-1116 alkoxides, 1065 amides, 1062,1066 amine oxides, 1065 amines, 1060 amino acids, 1066 aromatic amines, 1061 arsenic compounds, 1065 2,2 -bipyridyl, 1061... 

The C2-symmetric ligand l,8-bis(3-ieh-butyl-9-acridyl)naphthalene JV,JV -dioxide 89 (Scheme 31) forms a highly fluorescent scandium complex, used as enantioselective sensor for chiral amino acids. This compound allows for the measurement of the total amount as weU as the enantiomeric excess of a variety of amino alcohols at micromolecular concentrations (2006CC4242). The synthesis and an interesting ring-closure reaction of a very similar species are shown in Scheme 70 (see above). 

Using same strategy, a catalytic, enantioselective addition of amines to meso-epoxides was established employing a scandium-bipyridine complex in emulsion (Scheme 8.12). In this work, Kobayashi and coworkers demonstrated that high yields and excellent enantioselectivities could be achieved using an amphiphilic Lewis acid combined with chiral Hgand as the catalyst in water. This work offered a green method for the synthesis of a-amino alcohols, which are important... 

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