Scaffold thrombus formation

Stock et al. used P4HB scaffolds and tissue engineered the patch with a porosity of 95% and pore sizes in the range of 180-240 p,m by salt-leaching and solvent evaporation. The sheep autologous cells (endothelial, smooth muscle, and fibroblast cells) were seeded on the scaffold before implantation. Results confirmed that the cell-seeded implants induced progressive tissue regeneration with no thrombus formation, stenosis, or dilatation. 

Table 3). Mural thrombi may serve as a scaffold for subsequent cell proliferation and undergo organization. However, early thrombus formation alone is not responsible for the development of neointimal hyperplasia. As discussed earlier, controversial results on neointimal hyperplasia with thromboresistant stents have been reported. 

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