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Scaffold morphing

The observation that structural elements are conserved even through changing scaffolds led to the idea of scaffold morphing . Several scaffolds with proven activities are overlaid and combined to yield novel chemotypes. [Pg.841]

Replacing parts of a molecule with bioisosteres Scaffold hopping and scaffold morphing Compound cyclization, often using SBDD Ring opening... [Pg.334]

See other pages where Scaffold morphing is mentioned: [Pg.223]    [Pg.49]    [Pg.49]    [Pg.69]    [Pg.840]    [Pg.840]    [Pg.840]    [Pg.842]    [Pg.329]    [Pg.738]    [Pg.223]    [Pg.49]    [Pg.49]    [Pg.69]    [Pg.840]    [Pg.840]    [Pg.840]    [Pg.842]    [Pg.329]    [Pg.738]    [Pg.835]    [Pg.835]    [Pg.328]    [Pg.333]    [Pg.527]   
See also in sourсe #XX -- [ Pg.329 ]



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