Saturated ligands synthesis

Macrocycles that are saturated or have double bonds in only one part of the ring can be made independently or can be made by template synthesis96 where the presence of a metal ion controls the ligand synthesis. An important route is the Schiff base condensation reaction (eq. 9-3),... 

Langer J, Walther D, Gorls H. Saturated and unsaturated nickelalactones with N-heterocyclic carbene ligands synthesis and structures. J Organomet Chem. 2006 691 4874-4881. 

Palladium-catalyzed ketone synthesis B. The reaction mixture is saturated with carbon monoxide, which intervenes in step 2 by forming a palladium(II) carbonyl complex. Before the transmetalation (above referred to as step 3) takes place a rearrangement is interposed. The ligand Rmisa rji cd undergoes a [l,2]-shift from Pd(II) to the carbon atom of carbon monoxide, leading to the formation of an acylpalladium(II) complex with the structure P lllsa llra cd-(C=0)-Pd(-X) L j. With regard to the above-mentioned steps 3-4 it behaves like the acyl-Pd(II) complex of the ketone synthesis A and, after reductive elimination, i.e. in step 5, yields... 

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