Sarin memory impairment

The inhalation exposure to higli-level sarin induced in rats impaired memory proeesses seen at 1 month post-exposure... 

The protein kinase C (PKC) signaling pathway has been associated with modulation of A-methyl-D-aspartate (NMDA) receptor activity, motor behavior, learning, and memory, all of which are severely impaired in intoxication with sarin and similar OPs. There was a reduction in the immunoreactivity levels of betall-PKC and Zeta-PKC in the frontal cortex (up to 24 h), and in the striatum (up to 5 days) post-sarin exposure, in contrast to the increase in the immunoreactivity of both enzymes in the hippocampus or thalamus, following a IxLDso exposure to sarin. These observations suggest a role for both conventional and atypical PKC isozymes in OP-induced neuropathy in the rat and further support their role in cell death (Bloch-Shilderman et al., 2005). 

Kassa, J.. Krejeova, G and Vachek, J. (2002). Tbc impairment of spatial memory following Jow-levei sarin exposure and antidotal ti eatmcnt in rats, Acta Med. 45, 149-153,... 

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