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SANPAH

SANPAH (N-succinimidyl-6-(4 -azido-2 -nitrophenylamino)hexanoate) is a heterobifunctional crosslinking agent containing an NHS ester and a photoreactive phenyl azide group (Thermo Fisher). The NHS ester end can react with amine groups in proteins and other molecules, forming... [Pg.310]

Figure 5.21 The reaction sequence of crosslinking with sulfo-SANPAH involves first derivatizing an amine-containing molecule using its NHS ester end to create an amide bond. Exposure to UV light then causes ring expansion to the dehydroazepine derivative, which can couple with amines to form the final conjugate. Figure 5.21 The reaction sequence of crosslinking with sulfo-SANPAH involves first derivatizing an amine-containing molecule using its NHS ester end to create an amide bond. Exposure to UV light then causes ring expansion to the dehydroazepine derivative, which can couple with amines to form the final conjugate.
Figure 28.8 The heterobifunctional crosslinkers sulfo-SAND, SANPAH, and sulfo-SANPAH contain an amine-reactive (sulfo)NHS ester on one end and a photoreactive phenyl azide group on the other end. Sulfo-SAND allows release of conjugates by reduction of its internal disulfide bridge. Figure 28.8 The heterobifunctional crosslinkers sulfo-SAND, SANPAH, and sulfo-SANPAH contain an amine-reactive (sulfo)NHS ester on one end and a photoreactive phenyl azide group on the other end. Sulfo-SAND allows release of conjugates by reduction of its internal disulfide bridge.
Sulfo-SAND, SANPAH, and Sulfo-SANPAH all contain a nitrated phenyl azide photoreactive group. The presence of the nitro group shifts the optimal wavelength for photoactivation... [Pg.1017]

Sulfo-SANPAH Sulfosuccinimidyl-6-(4 -azido-2 -nitrophenylamino)hexanoate MW 492.39 18.2 A... [Pg.282]

A water-soluble version of this cross-linker also exists. Sulfosuccinimidyl-6-(4 -azido-2 -nitrophenylamino)hexanoate (sulfo-SANPAH) contains the negatively charged sulfonate group on its NHS ring, lending greater hydrophilicity to the compound. [Pg.263]

See other pages where SANPAH is mentioned: [Pg.310]    [Pg.310]    [Pg.311]    [Pg.311]    [Pg.311]    [Pg.314]    [Pg.1016]    [Pg.1016]    [Pg.281]    [Pg.281]    [Pg.282]    [Pg.282]    [Pg.283]    [Pg.284]    [Pg.112]    [Pg.261]    [Pg.261]    [Pg.262]    [Pg.262]    [Pg.264]   


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Amines SANPAH

Sulfo-SANPAH

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