Samples whole-body tissue sections

In the same fashion, IMS can be used to discriminate against potential isobaric species to improve analyte specificity in MSI experiments. Trim et al. (2008) demonstrated the utility of IMS to enhance detection of vinblastine in whole-body tissue sections. Sprague—Dawley rats were dosed intravenously with vinblastine, after which they were sacrificed 1 h postdose. After preparing the tissue section, the samples were analyzed on a QqTOF in MS/MS mode. CID occurred after the ions were separated by IMS, thus product ions can be... 

Techniques for quantitative ADME typically employ radiolabeled drugs to look at tissue distribution either in homogenized samples or by whole body autoradiography. Whole body autoradiography involving the location and quantification of radiolabeled material in thin frozen sections of tissue can be particularly useful. Plasma protein binding and metabolism studies also benefit from the use of radio-labeled material. 

Kertesz, V., Van Berkel, G.J. (2010) Liquid Microjunction Surface Sampling Coupled with High-Pressure Liquid Chromatography-Electrospray Ionization-Mass Spectrometry for Analysis of Drugs and Metabolites in Whole-body Thin Tissue Sections. Anal. Chem. 82 5917-5921. 

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