Sample-handling techniques INDEX

Sample handling and preparation techniques associated with HPIEC of proteins and peptides, are critical to the success of the separation. The field of sample preparation for biopolymer. separation has been reviewed by Wehr (6) and Majors (7). Further details can be found in works by Suelter (8), Brewer, Pesce and Ashworth (9) and in the subject indexes of Methods in Enzymology (10). 

RD techniques based on how to exploit the mean and variance information of responses. The concept of building quahty into a design is increasingly popular in pharmaceutical industry because of their practicality. There have been many attempts to integrate Taguchi s RD principles with well-established statistical techniques in order to model the response directly as a function of control factors (Shin and Cho, 2005). In practice, it is necessary to handle the responses sampled as time series data that called time-oriented response in this paper. The associated experimental format is shown in Table 1. x, y, s, and t represent the vector of control factors, mean, variance, and time index respectively. 

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