Salvia triterpenoids

Fig. 6.4 Triterpenoids isolated from Salvia kronenburgii Rech...

Keywords a-amyrin, diterpenoids. Salvia frigida, p-sitoserol, triterpenoids. 

In our study on the chemical constituents of Salvia frigida Boiss., we report here the isolation and identification of two oleanane type (componnd 1, 2) and two cycloartane type triterpenoids (compound 3,4) with the componnds a-amyrin 5 and P-sitoserol 6. The compounds have been characterized by UV/vix, IR, H NMR, NMR and MS spectroscopy. 

Ulubelen, A., Tan, N., Sbnmez, U., Toppu, G. 1997. Diterpenoids and triterpenoids from salvia multicaulis. Phytochemistry 47 899-901. 

Until now, we have isolated over 50 triterpenoids, about 100 diterpenoids, more than half being new compounds, a total of 15 sesquiterpenoides and sesterterpenoides, 40 flavanoides and several aromatic compounds. Recently we have studied quite a number of Salvia species and isolated various group of compounds. The structures of the new compounds are discussed below. 

Phytochemistry Flowering plant tops contain 0.01-0.04 % essential oil (similar to Salvia sclarea in composition) with a pleasant aroma. In leaves there were 47 mg% vitamin C, and seeds contained up to 19 % oil (Khalmatov 1964). Triterpenoids, including ursane, oleanane, and lupane derivatives were isolated from the aboveground parts (Savona et al. 1987). The roots were found to contain a number of caffeic acid derivatives (rosmarinic acid, Uthospetmic add B, etc.), diterpenes (royleanone, ferruginol, taxodione, etc.), and the steroid daucosterol (Tezuka et al. 1998). 

Savona G, Bruno M, Rodriguez B, Marco JL (1987) Triterpenoids from Salvia deserta. Phytochemistry 26(12) 3305-3308 Savoskin IP, Pekker EG, Kadirova RB (1971) Amino acids and vitamin potential of some plant species in the bean family (Leguminosae) found growing the the south-east Altai. In Rastitelnuiye Bogatstva Sibiri (Plant riches of Siberia). Nauka, Novosibirsk, pp 104—109 (in Russian)... 

Preparative TLC and high-resolution (HR) EI-MS were used for isolation of santolinoic acid, a new ursane-type triterpenoid, from Salvia santolinifolia [31]. Partitioning of the ethanolic extract with different solvents was followed by column... 

A comparison of one-dimensional low temperature TLC-MS (ID LT TLC-MS) and two-dimensional LT TLC LC-MS system with the purpose of Salvia lavandu-lifolia fingerprinting was made [34]. Essential oil samples were applied on silica gel 60 F254 plates, which were developed using toluene-ethyl acetate (95 5, v/v) at -10°C. TLC-MS interface (CAMAG) was used for the elution of compounds with methanol from TLC plates to either MS or HPLC-MS system. While the ID approach separated the constitnents of Salvia lavandulifolia into three groups on the basis of their polarity, the 2D approach enabled further resolution of compounds into subgroups, but neither enabled baseline resolution of all analytes. This is due to the complexity of Salvia lavandulifolia essential oil composition, which contains different monoterpenes, sesquiterpenes, monoterpenoids, sesquiterpenoids, diterpenoids, and triterpenoids. 

Ahmad, Z., Mehmood, Z., Ifzal, R., Malik, A., Afza, N., Ashraf, M., and Jahan E. 2007. A new ursane-type triterpenoid from Salvia santolinifolia, Turk. J. Chem., 31 495-501. 

Kuzma L, Skrzypek Z, Wysokinska H (2006) Diterpenoids and triterpenoids in hairy roots of Salvia sclarea. Plant Cell Tiss Org Cult 8 171-179... 

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