Salmonella pathogenesis

Bearson BL and Bearson SM. 2008. The role of die QseC quorum-sensing sensor kinase in colonization and norepinephrine-enhanced motility of Salmonella enterica serovar Typhimurium. Microb Pathogenesis... 

Fig. 5.1 Pathogenesis of Salmonella Typhimurium and Salmonella Typhi. Upon ingestion, Salmonella travel to the small intestine. The bacteria invade Microfold (M) cells and other intestinal epithelial cells through the apical surface to cause infection. (A). Salmonella Typhimurium remains localized in the small intestine and induces an inflammatory host immune response, resulting in bacterial clearance from immunocompetent individuals. (B). Salmonella Typhi escapes from intestinal epithelial cells at the basolateral surface of the intestinal epithelium, enters phagocytes, and evades the host innate immune response, resulting in systemic infection...

Bacteria have the ability to sense and respond to their surroundings. In vivo, Salmonella recognition of diverse environmental signals is essential for pathogenesis. TCRSs are primary factors in this process, with PhoPQ, PmrAB and the Res system mediating responses in vivo to modify the bacterial cell surface. Salmonella... 

Scherer, C., Miller, S. Molecular pathogenesis of Salmonellae. In Groisman, E. (ed), Principles of Bacterial Pathogenesis. Academic Press, San Diego, CA (2001), pp. 265-333. 

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