Saliva methadone

Moore L, Wicks J, Spiehler V, Holgate R. Gas chromatography-mass spectrometry confirmation of Cozart RapiScan saliva methadone and opiates tests. J Anal Toxicol 2001 25 520-4. 

Rosas, M.E., K.L. Preston, D.H. Epstein, E.T. Moolchan, et al., Quantitative determination of the enantiomers of methadone and its metabolite (EDDP) in human saliva by enantioselective liquid chromatography with mass spectrometric detection, J. Chromatogr. B Anal. Technol. Biomed. Life Sci., 796(2), 355-370, 2003. 

One of the most annoying physiological side effect of methadone use is a feeling of dryness in the mucous membranes of the mouth, eyes, and nose. This is caused by methadone reducing the secretion of saliva, tears, and mucous. Regular users of methadone refer to the dryness of the mouth as cotton mouth, since the feeling is akin to having one s mouth stuffed full of cotton. 

Gas Chromatography-Mass Spectrometry. In plasma, saliva or urine methadone and metabolites, sensitivity 20 ng/ml for methadone in plasma or saliva—G. I. Kang and F. S. Abbott, J. Chromat., 1982, 231 Biomed. Appl., 20, 311-319. 

Ahmadi, F., Rezael, H., Tahvilian, R. (2012). Computational-aided design of molecularly imprinted polymer for selective extraction of methadone from plasma and saliva and determination by gas chromatography, l.Chromatoar.A. 1270,9-19. 

Afkhami et al. [162] used a graphite paste electrode containing MWCNT modified by the electrodeposition of gold NPs from a HAuCl solution to successfully determine cefixime, methadone [163], and nitrite [164] in a pharmaceutical form, in urine and saliva in several food stuffs and water samples, respectively. Fe203... 

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