Saku disease

Dementi B. 1994. Ocular effects of organophosphates a historical perspective of Saku disease. J Appl Toxicol 14 119-129... 

Ohio, K. (1974). Long-term follow-up of chronic orgaiinphosphaie intoxication (Saku disease) with special reference to retinal pigmentary degeneration. Nii wn Ganka Gakki Zasshi 78, 237-243. 

Although the pathogenesis of "Saku Disease" has not been delineated in detail, there... 

Ishikawa, S., 1973. Chronic optico-neuropathy due to environmental exposure of organophosphate pesticides (Saku disease) - clinical and experimental study. Nippon Ganka Gakkai Sasshi. 77 1835. 

Ocular effects in acute OP poisoning, such as myosis and lachrymation, have been discussed in 10.3.1.1 and theses and other effects on parts of the eye such as the retina have been reviewed. A strange story is that of Saku disease, a syndrome comprising reduced visual acuity, myopia and/or astigmatism and optic nerve damage associated with OPs and seen in Japan. One possible explanation for this syndrome is enhanced susceptibility of Eastern races for the ocular effects of OPs, but the role if any of OPs in causing Saku disease has by no means been proven. 

Bai H, Saku K, Liu R, (Tribe Y, Yamamoto K, Arakawa K. Polymorphism of the apolipoprotein A-IV gene and its significance in lipid metabolism and coronary heart disease in a Japanese population. Eur J Clin Invest. 1996, 26 1115-1124. 

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