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Safety Margin of Inhalation Anesthetics

To assess the safety margin of an inhalation anesthetic, not only should the ED50 values but also the maximally effective dose and the dose with a minimal danger of fatal outcome be determined. In particular, cardiovascular parameters are observed (Kissin et al. 1983). [Pg.213]

Male Sprague Dawley rats weighing 300-350 g are placed into a clear chamber with the tail protruding from a special opening. An anesthetic-oxygen non-humidified mixture is directed into the chamber at a rate of 4 1/min. The inhalation anesthetics, e.g., halothane or isoflurane, are vaporized in Draeger vaporizers and the level in the chamber is monitored with a gas analyzer which is calibrated with a mass spectrometer. Rectal temperature is monitored and [Pg.213]

Loss of righting reflex. The test is regarded as positive if the animal fails to right itself with all four feet on the floor within 15 s after being placed in a side position. [Pg.213]

Prevention of purposeful movements response to a noxious stimulus. The animals are stimulated for 60 s by placement of a 1-kg weight on the middle of the tail. Only the purposeful movement of the head or legs is considered to be a response. [Pg.213]

Prevention of the heart rate increase to a noxious stimulus (ECG signals). An increase in heart rate of greater than 1 % is regarded as a positive response. [Pg.213]


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