Safety Considerations - The Column Shield Jacket

8 Scaling-up of Supercritical Fluid Chromatography to Large-Scale Applications 

It is essential to have a pressure regulating valve which has a small internal volume and has the capability of controlling the pressure independently of mobile phase mass flow rate. In addition to these features, it is desirable to heat the effluent stream to prevent blockages by solid particles of carbon dioxide and precipitated solutes caused by the self cooling of the fluid as it expands after depressurisation. The back pressure regulation on the latest system is by means of an electronically controlled valve described by Saito et al. [9] and manufactured by the Jasco Corporation of Japan. This device has proved to be much more reliable than the manually operated valve and has a very small internal volume. 

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