Saccharopine dehydrogenase

Fig. 24. Four out of five amino acid residues around the reactive cysteine are identical in yeast saccharopine dehydrogenase and sheep sorbitol dehydrogenase.

Blemings, K. P., Crenshaw, T. D., Swick, R. W., and Benevenga, N. J. (1994). Lysine a-ketoglutarate reductase and saccharopine dehydrogenase are located only in the mitochondrial matrix in rat liver. J. Nutr. 124,1215-1221. 

C11H20N2O6, Mr 276.29, mp. 240-248°C (decomp.), [a] 3 +33 go (0.5 m HCl), +8.1 ° (0.5 m NaOH), pK 2.6, 4.1,9.2, 10.3. A widely distributed non-proteinogenic amino acid in Saccharomyces cerevisiae, Candida utilis, Lentinus edodes, Agaricus bisporus, tobacco leaves (Nicotiana tabacum), and other plants. Metabolism S. is a direct precursor of lysine in the biosynthesis and the first product of lysine catabolism. The responsible enzyme is saccharopine dehydrogenase (EC 1.5.1.8). S. is degraded to 2-aminoadipic acid... 

Saccharopine dehydrogenase (NADP, L-lysine-forming) (EC 1.5.1.8) and Saccharopine dehydrogenase (NAD, L-glutamate-forming) (EC 1.5.1.9). Elevated plasma lysine. (0.2-1.5 mmol/1). Increased urinary lysine, N-acetyllysine, homocitrulline and homo-... 

I Homocitrate synthase 2 homocitrate dehydratase 3 homoaconitate hydratase 4 homoisocitrate dehydrogenase 5 2-aminoadipate aminotransferase 6 aminoadipate semialdehyde dehydrogenase 7 saccharopine dehydrogenase (L-glutamate forming) 8 saccharopine dehydrogenase (L-lysine forming)... 

---