Saccharides biologically active

Fig. 5. Structure and biological activities of Kiessling s initial carbohydrate-substituted polymers generated by ROMP. Relative inhibitory potency the saccharide residue concentration needed to inhibit the agglutination of red blood cells mediated by the protein concana-valin A... 

Fig. 6. Comparison of the biological activities of monovalent glucose and mannose derivatives, multivalent carbohydrate-substituted polymer with two saccharide epitopes per repeat unit, and the less sterically congested carbohydrate-substituted polymer with a single recognition element per repeat unit. All polymers were generated by ROMP using RuC13...

Glycoproteins contain both saccharide and protein moieties with the protein being the major component, but both portions are involved in the overall biological activities. 

O-Glycopeptides and glycoconjugates, in which the saccharide is linked to a peptide or a protein through a linear or a branched aliphatic spacer, have been used to enhance biological activity. 298 301 373,472,481-483 Peracetylated galabiose and lactose react with 3-sulfanylpropanoic acid in the presence of BF3 and the products have been used in the synthesis of HEL(46-61) and shorter fragments thereof. 164 ... 

A sulfated saccharide mimetics which inhibit cell adhesion and migration are lead compounds towards a biologically active biodegradable drug. Presented at Eurocarb 14, Liibeck, 2 July 2007. 

Parrot-Lopez, H., Leray, E., Coleman, A. W. New (3-cyclodextrin derivatives possessing biologically active saccharide antennae. Supramol. Chem. 1993, 3, 37-42. 

The biological activities of sHA can be sequence specific, an example of which is the report that sHA tetrasaccharides up-regulate the expression of heat-shock protein 72 as well as the corresponding mRNA and suppress cell death under stress condition, while the corresponding di-, hexa- and octa-saccharides are inactive (25). To date, the majority of biological studies is performed using... 

Combinatorial methods for the identification of biologically active carbohydrates are evolving. Generation of random glycosylation-based libraries as heterogeneous mixtures have given way to focused libraries that employ discrete saccharide cores. 

In gel chromatography of biological systems, water-based eluents are dominant. The main reason for using the aqueous miUeu is both the low solubility and susceptibility to the irreversible denaturation of many biologically active substances in organic solvents. However, pure water is applied only exceptionally, e.g., when separating saccharides. In the majority of applications, one works with the aqueous solutions of various substances, which means with the mixed eluents, and therefore the above mentioned problems are often encountered. 

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