SAAM computer program

The SAAM (Simulation, Analysis And Modeling) computer program developed by Berman and Weiss (8) was used to analyze the isotope dilution and balance data. The observed time dependent dilution of both calcium tracers in plasma, as reflected in urine at longer times, coupled with their cumulative appearance in urine and feces is used to calculate kinetic parameters of the model. The balance data are then used to calculate the steady state... 

Lyne, A., Boston, R., Pettigrew, K., and 2 ech, L. (1992). EMSA A SAAM service for the estimation of population parameters based on model fits to identically replicated experiments. Comput. Methods Programs Biomed. 38,117-151. 

The time of administration of the KI relative to the exposure to radioiodine is the critical determinant of effectiveness of blockade, (irin 1972, Blum 1967, Lengemann 1963,. Stanbury 1990) Using computer simulation (Berman s SAAM program) based on our compartmental model of iodine metabolism, we have systematically investigated the effect of the time of KI administration on blockade effectiveness. In Figures 3 and 4, th)n oid uptake, in percentage of administered activity, is plotted against the time interval between KI administration und 131 131... 

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