S- 5-amino-5-

Fig. 17 (a) Chemical structure of polythiophene poly((3,3"-di[(S)-5-amino-5-carbonyl-3-oxapen-tyl]-[2,2 5 2"])-5-,5"-terthiophenylene hydrochloride), PONT, (b) Emission spectra of 6.5 pM PONT—HC1 (on a chain basis) in 25 mM HC1 (black spectrum), 25 mM HC1 with 5.0 pM of native bovine insulin (blue spectrum), 25 mM HC1 with 5.0 pM fibrillar bovine insulin (red spectrum). The emission spectra were recorded with excitation at 400 nm [31]... 

The chiral polythiophene, poly(3- (.S )-5-amino-5-carboxyl-3-oxapcntyl -2,5-thiophenylene) hydrochloride, l-POWT, ring-functionalized with the amino acid L-serine, has been synthesized by Inganas and coworkers,69,168 and was found to exhibit pH-dependent UV-visible, fluorescence emission, and CD spectra. At a pH equal to the isoelectric point of the amino acid, the poly thiophene chains separate and adopt a nonplanar right-handed helical conformation. Increasing the pH leads to a more planar conformation of the backbone and aggregation of the polymer chains. 

HO-5, azide substitution, and hydrogenolysis led to the precursors of 58 and 59, respectively. Also, the (S)-5-amino-5-deoxy-4-methoxypentanoic acid (60) was prepared from D-ribono-1,4-lactone (via its 2-bulenolide) and from L-glutamic acid, as depicted in Scheme 14.53 Compound 60 was N-protected and carboxylate activated to give 6L The... 

Amino-5 -deoxy-2, 3 -0-isopropylideneadenosine was acylated at N-5 with an activated derivative of the 6-carboxy-2-naphthyl ester of Kemp s acid imide. The resulting molecule possesses self-complementary binding sites, the key feature of replicating molecules that act as templates for their own reproduction. The dimer of this molecule is, however, not very stable K = 630 L mol ). When the two initially mentioned educts are added, a small proportion of the ternary complex is also formed and undergoes a fast, template-catalysed... 

The results of inhibition studies with aldonolactones and 5-amino-5-deoxyaldonolactams may be summarized as follows y -D-glycosidases are inhibited by 1,5-lactones and the lactams some 100- to > 10,000-fold better than by the parent aldoses, with Kj values from 200 //Mto <0.1 nM. Al-dono-1,4-lactones are probably no better inhibitors than aldoses or polyols of comparable structure, with the possible exception s of 2-acetamido-2-deoxy-D-glucono-1,4-lactone. 

L-Arginine S(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid (L-arg)... 

NN/S 2-Amino-5.6-dihydrothiazolo[3,2-A][l,2,4]triazole 42 <2003JHC821> 2-(3 -chlorophenyl)-5,6-dihy-drothiazolo[3,2-A][l,2,4]triazole 43 <1997AJC911> 5-iodomethyl-2-phenyl-5,6-dihydrothiazolo[3,2-A][l,2,4]triazole 44 <2004CHE1207, 1999RJOC730> 6,7-dimethoxy-3-methyl-l-(4-nitrophenyl)-iV-(5, 6 -dihydrothiazolo[3,2-... 

S, 5.S )-5-[(Benzyloxycarbonyl)amino]-2-(2-aminopropyl)-6-(indol-3-yl)-4-oxohexanoic Add Hydrochloride Salt (22, R1 = 3-methylindolyl R2=2-NH2Pr) ... 

Hassall CH, Ogihara Y, Thomas WA (1971) Amino-Acids and Peptides. Part XI. (3/ ,5S)-5-Chloropiperazic Acid and (3,S, 5,Sj-5-Hydroxypiperazic Acid, Products of Hydrolysis of Monamycin. J Chem Soc (C) 522... 

Most remarkably, catalyst loadings could be reduced to 1.25 mol%, resulting in total turnover numbers > 50 (Table 6.3) [247]. Catalyst 233 is readily available in large quantities because its synthesis is based on (S,S)-(+)-5-amino-2,2-dimethyl-4-phenyl-l,3-dioxane, an intermediate of industrial chloramphenicol production... 

S)-2-Amino-5-(l,3-dioxolan-2-yl)-pentanoic acid [allysine ethylene acetal (4)] is one of three building blocks used for an alternative synthesis of omapatrilat, a vasopeptidase inhibitor [13,14], It has previously been prepared in an eight-step synthesis from 3,4-dihydro-2H-pyran [23],... 

Scheme 2.30 Synthesis of l-aminoindan-l,5-dicarboxylic acid (AIDA) and (/ S)-l-amino-5-phosphonoindan-l-carboxylic acid (APICA) (known antagonists of metabotropic glutamate and G-protein-coupled receptors) using the L-proline-catalyzed enantioselective a-amination reaction.

S)-2-amino-5-(1, 3-dioxolan-2-yl) pentanoic acid (allysine ethylene acetal)... 

The polyoxins (56) formed by S. cacaoi contain a 5-amino-5-deoxy-D-allofuranosyluronic acid residue. The biosynthesis of the polyoxins... 

Sulfoximid S-(2-Amino-5-chlor-phenyl)-S-phenyl- Ell, 1304 (R2SO + HN3)... 

Proof that 5-amino-5-deoxy-D-xylose exists in the six-membered ring-form 34 was afforded by the following reactions. N-Acetylation with acetic anhydride in alkaline solution gives 5-acetamido-5-deoxy-D-xylopyranose (35) (see Section III, 1, p. 167), isolated - in a yield of 45-50% no furanose form is found in the mother liquor. Reduction with sodium borohydride gives only the piperidine derivative 32 and no 5-amino-5-deoxy-D-xylitol. Catalytic hydrogenation affords 32 in quantitative yield. However, the latter reaction does not suffice to prove the exclusive presence of the six-membered ring-form 34, (29) S. Hanessian, Chem. Ind. (London), 2126 (1966). 

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