Ruthenium-catalyzed synthesis

Abstract Heterocyclic compounds have been synthesized by means of stoichiometric reagents under acidic or basic conditions. Recent progress of homogeneous transition-metal catalysis realizes a highly selective and atom-economical methodology for synthesis of heterocycles under neutral and mild conditions. This review highlights the recent advances in the area of ruthenium-catalyzed syntheses of heterocyclic compounds. 

A related intramolecular N-alkylation leading to saturated nitrogen heterocycles 99 can proceed via dehydration of intermediates 98 (Eq. 39) [96]. Unsaturated nitrogen heterocycles such as pyrroles [97], indoles [98], benzo-azoles [99], 2,3-dihydroimidazol-2-ones [100], and imidazo[l,2-a]pyridines [101] were obtained through similar cyclocondensation reactions. Interesting ruthenium-catalyzed syntheses of quinolines have been achieved by means of cyclocondensations of aniline derivatives with propanediols, aminoalcohols, or... 

Itoh K, Yamamoto Y (2004) Ruthenium Catalyzed Synthesis of Heterocyclic Compounds. 11 249-276... 

Jones and co-workers reported the ruthenium-catalyzed synthesis of indol derivatives in a single step starting from di-o,o -substituted aromatic isonitriles a representative example is shown in Scheme 77 366>366a... 

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