Applications of Ruthenium-Catalyzed Olefin Metathesis in Organic Synthesis

Applications of Ruthenium-Catalyzed Olefin Metathesis in Organic Synthesis 

Olefin metathesis reactions are attractive transformations in organic synthesis for many reasons. Chief among them are (i) the reliability of the reactions and the catalysts and (ii) the relative simplicity of these transformation, as they normally involve readily available substrates and do not require protecting groups for reactive functionalities. 

---

Applications of Ruthenium-Catalyzed Olefin Metathesis in Organic Synthesis 163 6.3.1.2 Synthesis of Medium-Sized Rings using RCM... 

This chapter is concerned specifically with olefin metathesis reactions catalyzed by ruthenium-carbene complexes, mainly because of their great success during recent years. We begin with an overview of these catalysts, and then focus on mechanistic considerations that are important for understanding the reactivity profiles of various catalyst derivatives. The second part of the chapter deals with applications of ruthenium-catalyzed olefin metathesis, especially RCM, CM, and combination processes in organic synthesis. 

---