Ru II Catalyzed Enantioselective Hydrogen Transfer

Although catalytic transfer hydrogenation of ketones to alcohols with 2-propanol, according to this scheme, offers an attractive alternative to the reaction with di-hydrogen (molecular hydrogen), it encountered inherent chemical problems when 

Successful application of the (f ,f )-Ru(II) catalyst 19 in the synthetic route to montelukast sodium is an elegant example of how fundamental knowledge of a catalytic process enables development of a robust and effective catalyst, which is useful on an industrial scale in the synthetic development of a chiral drug. 

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