Rr- Tc

Kota J, Chivukula RR, O Donnell KA, Wentzel EA, Montgomery CL, Hwang HW, Chang TC, Vivekanandan P, Torbenson M, Clark KR, Mendell JR, Mendell JT (2009) Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell 137 1005-1017... 

Results in Table 31.3 indicate that the combination of TS and TC descriptors resulted in a highly predictive RR model = 0.895) the addition of three-dimensional and QC indices to the set of independent variables did not result in significant improvement in model quality. It may be noted that we have observed such results for various other physicochemical and biological properties including mutagenicity [25,54], boiling point [55], blood air partition coefficient [37], tissue air partition coefficient [46], etc. [24,30,45,56]. Only in limited cases, e.g., halocarbon toxicity [12], the addition of QC indices after TS and TC parameters resulted in significant improvement in QSAR model quality. 

Important Topological Descriptors for the Prediction of VP, Based on t Value, from the TS + TC RR Model... 

The [Tc=N] core is second only to the [Tc=0] core in its importance for the coordination chemistry of technetium in the context of radiopharmaceutical applications. The nitrido ligand N is isoelectronic with the 0x0 o ligand and with the imido R—ligand. The highly negative charge makes the nitrido ligand a very powerful rr-donor, well able to stabilize the... 

Notes TC 15 — hang in the center TC 16 — drain. Total thermocouples = 16. Abbreviations LR = left rear RR = right rear LF = left front RF = right front CR = center rear CC = center center CF = center front. 

This holds when tc = rr otherwise, if tc < rr, the average should be performed on the integral value and the F function cannot be extracted from the integral. However, the final results are unchanged if H0 is isotropic. 

Love RR, Hutson PR, Havighurst TC, Cleary JF. Endocrine effects of tamoxifen plus exemestane in postmenopausal women with breast cancer. Clin Cancer Res 2005 11 1500-3. 

T < Tc. m2 < 0 and the minimum free energy is at A 2 = —(rr /lX) > 0. This is an analogy with the case of spontaneous symmetry breaking in the vacuum, where there is a difference of free energy (or latent free energy) on the classical level that can be used for practical devices. 

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