Roxithromycin Cyclosporine

Clinically important, potentially hazardous interactions with alprazolam, amiodarone, amphotericin B, arbutamine, bendroflumethiazide, benzthiazide, bisacodyl, bumetanide, carbimazole, chlorothiazide, chlorthalidone, cholestyramine, clarithromycin, conivaptan, cyclosporine, cyclothiazide, dan-shen, demeclocycline, devil s claw, dexmedetomidine, doxycycline, erythromycin, esomeprazole, ethacrynic acid, flunisolide, furosemide, ginseng, glycopyrrolate, glycopyrronium, hawthorn (fruit, leaf, flower extract), horsetail, hydrochlorothiazide, hydroflumethiazide, indapamide, licorice, lopinavir, mepenzolate, methyclothiazide, metolazone, minocycline, mistletoe, oxprenolol, oxytetracycline, paroxetine, phenylbutazone, polythiazide, propafenone, propantheline, quinethazone, quinidine, rabeprazole, rifampin, roxithromycin, sarsaparilla, senna, Siberian ginseng, squill, St John s wort, telithromycin, teriparatide, tetracycline, thiazide diuretics, tolvaptan, trichlormethiazide, verapamil... 

Clinically important, potentially hazardous interactions with atorvastatin, bexarotene, cyclosporine, dicumarol, ezetimibe, fluvastatin, interferon alfa, lovastatin, nicotinic acid, pioglitazone, pravastatin, repaglinide, rosuvastatin, roxithromycin, simvastatin, statins, warfarin... 

Clinically important, potentially hazardous interactions with amiodarone, atazanavir, azithromycin, bosentan, ciprofibrate, clarithromycin, clopidogrel, cyclosporine, darunavir, delavirdine, diltiazem, erythromycin, fosamprenavir, fusidic acid, gemfibrozil, grapefruit juice, imatinib, itraconazole, lopinavir, rabeprazole, ranolazine, red rice yeast, ritonavir, roxithromycin, selenium, St John s wort, tacrolimus, telithromycin, tipranavir, verapamil, warfarin... 

Billaud E M, Guillemain R, Fertineau N, Kitzis M-D, Dreyfus G, Amrein C, Kreft-Jais C, Husson J-M, Chretien P. Interaction between roxithromycin and cyclosporin in heart transplant patients, Clin Pharmacokinet (1990) 19,499-502. 

Moravek J, MatouSovic K, Prdt V, Sedivy J. Pharmacokinetics of roxithromycin in kidney grafted patients under cyclosporin A or azathioprine immunosupfressicn and in healthy volunteers. IntJ Clin Pharmacol Ther Toxicol (1990) 28,262-7. 

D properties were calculated from the structures shown, while 3D properties were computed from available X-ray crystal structures of rifampicin (CSD60-RIFAMP), roxithromycin (CSD-FUXYOM), cyclosporine A (CSD-DEKSAN), and rapamycin (CSD-RAPMCNll). ... 

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