Rotenone mitochondrial

Other experimental data indicate that the oxygen is affecting nitrite accumulation by increasing nitrite reduction. When conditions are optimized for entry of rotenone (mitochondrial site I inhibitor) into leaf secticHis the leaves under aerobic conditicHis accumulated one-half as much nitrite as those without rotenone under anaerobic conditions (Hageman et al., 1980b Reed and Hageman, 1977). The rotenone treatment reduced respiration by... 

Insects poisoned with rotenone exhibit a steady decline ia oxygen consumption and the iasecticide has been shown to have a specific action ia interfering with the electron transport iavolved ia the oxidation of reduced nicotinamide adenine dinucleotide (NADH) to nicotinamide adenine dinucleotide (NAD) by cytochrome b. Poisoning, therefore, inhibits the mitochondrial oxidation of Krebs-cycle iatermediates which is catalysed by NAD. 

Similarly, abnormalities in the mitochondrial machinery and resulting oxidative stress may also intervene in Parkinson s disease (PD) [31, 32]. The decreased activity of mitochondrial complex I in PD patients [33], and the preferential toxicity of the complex I inhibitor rotenone [34] and MPP+ (the active metabolite of MPTP)... 

S. Tada-Oikawa, Y. Hiraku, M. Kawanishi, and S. Kawanishi, Mechanism for generation of hydrogen peroxide and change of mitochondrial membrane potential during rotenone-induced apoptosis. Life Sci. 73, 3277-3288 (2003). 

Usually, mitochondrial superoxide production is registered only after the incubation of submitochondrial particles with respiratory inhibitors, first of all, rotenone and antimycin. Under such conditions, superoxide production may achieve about 1 nmol 1 1 min 1 per mg of... 

It is important that mitochondrial oxygen radical production depends on the type of mitochondria. Recently, Michelakis et al. [78] demonstrated that hypoxia and the proximal inhibitors of electron transport chain (rotenone and antimycin) decreased mitochondrial oxygen radical production by pulmonary arteries and enhanced it in renal arteries. This difference is probably explained by a lower expression of the proximal components of electron transport chain and a greater expression of mitochondrial MnSOD in pulmonary arteries compared to renal arteries. 

Furthermore, Marshall et al. developed the extractable MBF tracer 7 -[ F] fluoro-6, 7 -dihydrorotenone (p F]FDHR) [72]. p F]FDHR is a derivative of the neutral and lipophilic lead compound rotenone that binds to the complex I of the mitochondrial electron transport chain [73-76]. It was prepared from 7 -tosyl-oxy-6, 7 -dihydroroten-12-ol (DHR-ol-OTos) in two steps. After nucleophilic substitution of DHR-ol-OTos with p F]fluoride, the intermediate was oxidized with manganese dioxide to yield the target compound [ F]FDHR (Fig. 11). 

In addition to their potential as antitumor agents, acetogenins have great potential as natural "organic" pesticides (Mikolajczak et al., 1988,1989 McLaughlin et al., 1997). Bullata-cin (1) and trilobacin (3) (see Figure 13.1) were more potent than rotenone, a classic complex I mitochondrial inhibitor, in a structure-activity relationship (SAR) study using yellow fever mosquito (YFM) larvae (He et al., 1997). 

Mitochondrial electron transport system Rotenone, hydramethylnon, Pyridaben, tolfenpyrad, HCN, phosphine, acequinocyl, fenazaquin, pyrimidifen, tebufenpyrad, fenpyroximate, fluacrypyrin Inhibition... 

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