Rotavirus receptors

Different gangliosides have been found to be involved in rotavirus entry, and the results of these studies have recently been reviewed in detail [10]. Briefly, porcine rotaviruses have GM3 [177] and GDla [173] receptors. Simian rotavirus 11 binds to GM3, GM2, and GDla [178, 179] GM3 containing both iV-acetyl- and Af-glycolyl-neuraminic acid may represent the receptors of bovine rotaviruses [178]. Human rotavirus bound to GMl [173, 180]. 

Bastardo JW, Holmes IH (1980) Attachment of SA-11 rotavirus to erythrocyte receptors. Infect Immun 29 1134-1140... 

Kuhlenschmidt MS, Rolsma MD, Kuhlenschmidt TB, Gelberg HB (1997) CharacterizatiOTi of a porcine enterocyte receptor for group A rotavirus. Adv Exp Med Biol 412 135-143... 

Sodium dodecyl sulphate readily inactivates rotavirus, an enteric pathogen belonging to the Reoviridae it also causes loss of poliovirus infectivity-by disruption of virion proteins [83, 84]. Non-infective rotaviral particles lack the outer protein shell associated with infectivity. The initial step in infection of a cell by a virus is the adsorption of the virus to receptors on the surface of the cell. The outer layer of the viral particle must be obviously involved in this process and alterations to the capsid, say by detergent, may lead to a loss of adsorptive capacity and thus a loss in activity. NaDS causes such a loss in the ability of the rotavirus to adhere to CV-1 cells. However, most of the proteins of the outer shell seem to remain associated with the virions and the decreased adsorption may be an electrostatic effect due to adsorption of NaDS molecules on the virus surface. 

Svensson, L., 1992, Group-C rotavirus requires sialic acid for erythrocyte and cell receptor binding, 7. Virol. 66 5582-5585. 

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