Rosiglitazone combination studies

Combination Studies with Rosiglitazone Plus Sulfonylurea, Metformin or Insulin... 

In another study the combination of a thiazolidinedione with insulin increased the prevalence of edema and the dose of thiazolidinedione was important (95). Of 319 patients taking insulin, 13% developed edema when taking rosiglitazone 4 mg/day compared with 16% taking 8 mg/day and 4.7% taking placebo (96). 

Polycystic ovary syndrome (PCOS) is characterized by menstrual irregularities, infertility, hyperandro-genism, obesity, and insulin resistance. In a study of rosiglitazone (4 mg twice daily for 2 months) with or without clomiphene in 25 women with PCOS who had not responded to clomiphene alone, ovulatory rates were higher in the combined versus monotherapy groups (77% and 33%, respectively) [53]. 

Rosiglitazone has been studied in combination with acarbose, digoxin, metformin, nifedipine, ranitidine, warfarin, and oral contraceptives [67,72] There have been no clinically significant effects on the pharmacokinetics of any of these agents in combination with rosiglitazone. 

Home PD, Pocock SJ, Beck-Nielsen H, Curtis PS, Gomis R, Haneteld M, Jones NP, Komajda M, McMurray JJV. For the RECORD study team. Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD) a multicentre, randomised, open-label trial. Lancet 2009 373 2125-35. 

Drug-drug interactions Fenofibrate Urothelial cells co-express PPARa and PPARy, and an interaction study with rosiglitazone (PPARy agonist) and fenofibrate (PPARa agonist), alone or in combination, showed S5mergy in inducing... 

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