Role of Mobile Phase in Enantiomer Separation

In chromatographic enantiomer separation, reversed-phase mobile phase condi- 

A considerable number of papers dedicated to SFC-based enantiomer separation have been published [89-92], yet httle is known on the mode of chiral recognition under these conditions. SFC appears to be capable of reproducing many chiral separations accomplished under normal-phase condihons, but with superior efficiency and in some cases enhanced selechvity. This suggests that the chiral recog-nihon modes operating in SFC may follow mechanisms closely related to those operahve under normal-phase conditions. 

Chiral Selectors and Chiral Stationary Phases Employed in Liquid Chromatographic Enantiomer Separation 

In the course of the development of CSPs, a broad variety of chiral molecules (and materials) has been the subject of scrutiny with respect to chromatographic enantiomer separation capacity. The chiral molecules studied as potential SOs cover virtually the entire chemical and structural diversity space, ranging from low-molecular-weight compounds to polymers of both synthetic and biological origin. So far, the (stiU ongoing) quest for efficient SOs has resulted in the synthesis of more than 1400 CSPs [94], the properties of which are documented in an almost intractable number of dedicated scientific publications. The outcome of these efforts is manifest in an enormously rich toolbox of more than 200 commercially available CSPs offered by various speciahzed suppliers. 

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