Role of Chemistry in the MLSCN

Two distinct aspects of the MSLCN require participation by, and input from chemists first, synthetic chemistry is a source of compounds within the screening library, and therefore of the assay hits and second, expertise in synthetic and medicinal chemistry is required to optimize the hits into usable probes of biological systems. 

Each screening center has medicinal and synthetic chemistry expertise in order to optimize hits identified from HTS campaigns and develop them into chemical probes. Specific capabilities vary, however typical strategies employed include parallel synthesis, computational and informatics analysis, and analytical capabilities such as LC/MS techniques. The structures of novel compounds that are prepared, their synthetic protocols, analytical data and biological data are all available, and samples of final probes developed are deposited into the MLSMR. A Working Group comprised of chemists from each center meets regularly to share information, best practices, and insure optimal use of resources. 

3 Pilot Scale Libraries and Chemical Methodologies and Library Development Centers 

Another key component of the Molecular Libraries Initiative is the development of novel technologies for generating chemical diversity, the application of those 

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