Role in cell growth

Hunter, T., The Croonian Lecture 1997. The phosphorylation of proteins on tyrosine its role in cell growth and disease, Philos. Trans. Roy. Soc. London B (Biol. Sci.), 353, 583-605, 1998. 

The PI3-K/PKB pathway is another key cellular signaling pathway that plays an important role in cell growth, survival, proliferation, and gene expression. PKB, also known as Akt, exists in three isoforms PKBa/Aktl, PKB(3/Akt2, and PKBy/Akt3 each isoform possesses an amino-terminal PH domain, a kinase... 

S ATP -I- protein <140> (<140>, CSK phosphorylates other members of the src-family of tyrosine kinases at their regulatory carboxy-terminus. By regulating the activity of these kinases, CSK may play an important role in cell growth and development [385]) (Reversibility <140> [385]) [385]... 

Many are known to have important roles in cell growth and division, e.g. Myc, Jun and Fos (see... 

In order to further understand the functions of ascorbate that may occur at the plasma membrane, we review here the participation of this vitamin as a prooxidant in the electron transport in this organelle and its role in cell growth control. We include here also the special role of the ascorbate system in plant cells. Relationships of both ascorbate function and its recycling in the plasma membrane with other known mechanisms of growth control are also considered in an attempt to present the integration of extracellular ascorbate in cell physiology as a whole. 

Balanol, a metabolite produced by the fungus Verticil-Hum balanoides, was isolated and characterized in 1993, and it shows remarkable inhibitory properties toward the protein kinase C (PKC—a family of phospholipid-depen-dent serine/threonine protein kinases) that plays an important role in cell growth, signal transduction, and differentiation. The synthesis of the key intermediate to the (—)-balanol hexahydroazepane core 126, which includes an enantioselective hydrogenation via DKR was reported by Genet et The a-amido p-keto ester... 

Boutros, T., Chevet E., and Metrakos, R (2008). Mitogen-activated protein (MAR) kinase/MAP kinase phosphatase regulation roles in cell growth, death, and cancer. Pharmacol. Rev. 60(3), 261-310. 

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