Roch Laboratories

E. Squires and R. Qeeland, Microbiology and Pharmacokinetics of Parenteral Cephalosporins, Roche Laboratories, Nudey, N.J., 1985. [Pg.41]

A system was developed at Roche Laboratories whereby a sheet (or web ) was coated with a drug/binder mixture. The solid dosage units were then punched from the web [168]. This system was very flexible and amenable to immediate release and sustained-release technologies. However, due to the im-practicality of the system, it was abandonned in the mid-1980s and is only of historical significance. [Pg.334]

Mibefradil Posicor Roche Laboratories Blood pressure, cardiovascular 6/20/1997 6/8/1998 1 year Drug interaction. Not available lowered heart rate in women ... [Pg.502]

The benzodiazepines were discovered by Leo Sternbach at the Hoffman-La Roche laboratories, and their pharmacology was elucidated by Randall of the same company. An enormous variety of these compounds exist. Since about 3500 benzodiazepine compounds have been investigated, the neurologic structure-activity relationships of these drugs have been well established and the central features can be generalized as follows ... [Pg.274]

Similar labeling language also in the labeling of INVIRASE (Roche Laboratories) (saquinavir mesylate) capsules, December 2003 KALETRA (Abbott) (lopinavir/ritonavir) capsules, (lopinavir/ritonavir) oral solution, February 2004 and LEXIVA (GlaxoSmithKline) (fosamprenavir calcium) tablets. May 2004. [Pg.258]

Brand Name/ Company Septra /Glaxo Wellcome Inc. Bactrim /Roche Laboratories ... [Pg.43]

Kabi Vitrum, Stockholm, Sweden Roche Laboratories Inc., Nutley, New Jersey Astra Zeneca, Wilmington Delaware Bristol-Myers Squibb, Princeton, New Jersey Hospira, Lake Forest, Illinois InvensysAPV, Denmark MicroLuidics, Newton Massachusetts Five Star Technologies, Cleveland, Ohio Abitec Corp, Columbus, Ohio BASF, Mount Olive, New Jersey Sasol North America Inc., Houston, Texas Uniqema North America Inc., Chicago, Illinois Stepan Company, NorthLeld, Illinois Novartis Pharmaceuticals Corporation, East Hanover, New Jersey... [Pg.221]

Roche Laboratories Hoffmann - La Roche Inc. Roche Laboratories Roche Laboratories... [Pg.3011]

The de novo discovery synthesis of capecitabine (1) was reported by the Nippon Roche Research Center scientists9,19 and was followed up with a preparation invented by a team at the Hoffinann-La Roche laboratories in New Jersey for the conversion to 1 from 5 -DFCR (10).2° In the first route, 5-fluorocytosine (15) was mono-silated using one equivalent of hexamethyldisilazane in toluene at 100 °C followed by stannic chloride-catalyzed glycosidation with known 5-deoxy-l,2,3-tri-0-acetyl-p-D-ribofuranoside (17) in ice-cooled methylene chloride. While this procedure provided the 2, 3 -di-0-acetyl 5-fluorocytidine 18 in 76% yield on a 25-g scale, an alternative method was also devised using in situ-generated trimethylsilyl iodide in acetonitrile at 0°C to provide a 49% yield of 18 on smaller scale. Acylation of the N -amino group of the bis-protected 5 -DFCR derivative was accomplished by the slow addition of two equivalents of -pentyl chloroformate to a solution of 18 in a mixture of pyridine and methylene chloride at -20 °C, followed by a quench with methanol at room temperature to provide the penultimate intermediate 19 on 800-g scale. The yield of intermediate 19 was assumed to be quantitative and was subjected to the final deprotection step, with only a trituration to... [Pg.64]

Xeloda (capecitabine) prescribing information. Roche Laboratories, Inc. www.gene.com/gene/products/information/xeloda, revised Nov. 2009, accessed Dec. 1,2009. [Pg.71]

DE Cadwallader. Biopharmaceutics and drug interactions. Nutley, New Jersey Roche Laboratories, 1971. [Pg.270]

Brand name Rocephin Manufacturer Roche Laboratories... [Pg.52]

Invirase , saquinavir mesylate [package insert]. Nutley, NJ Roche Laboratories, Inc. (package insert revised 12/2003). [Pg.244]

Halstenson CE, Matzke GR. Bumetanide a new loop diuretic (Bumex, Roche Laboratories). Drug Intell Clin Pharm 1983 17(ll) 786-97. [Pg.567]

Anap hyl actoi d reacti ons/Anap hyl axi s (1992) Roche Laboratories Monograph Angioedema (5%)... [Pg.620]

Klonopin package insert. Roche Laboratories, Nutley, NJ, July 2001. [Pg.1304]

DuPont 302-992-5000 Jansen, Inc. 1-800-652-6227 Pfizer, Inc. 1-800-646-4455 Roch Laboratories 1-800-443-6676 Upjohn Co. 616-323-6332... [Pg.278]

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