Robinson Annelation Reactions in a One-Pot Process

Ecologically and economically valuable solvent-free Robinson annelation reactions, which proceed efficiently in a one-pot process at room temperature, have been reported [ 10]. For example, 2-methylcyclohexanone (59), methyl vinyl 

Complexation with a Chiral Host in a Water Suspension Medium 

Some solid-solid reactions were shown to proceed efficiently in a water suspension medium in Sect. 2.1. When this reaction, which gives a racemic product, is combined with an enantioselective inclusion complexation with a chiral host in a water suspension medium, a unique one-pot preparative method of optically active product in a water medium can be constructed. Some such successful examples are described. 

The enantioselective inclusion complexation of the reaction product with lOa-c in aqueous medium is more efficient than that by the recrystallization method. For example, inclusion complexation of rac-65e with 10a,b did not occur by recrystallization from an organic solvent however, enantioselective complexation occurred efficiently in aqueous medium to give finally optically active 65e [12]. 

Host Ketone Inclusion complex From complex From filtrate  

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In spite of all these steps, chemists do not usually consider the Robinson annelation a tandem reaction. This is partly because it is an old reaction but partly because each intermediate would, if isolated, give the same reaction as in the one-pot process. We shall describe as tandem reactions only those that have... 

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